Search results for "Arterial calcification"
showing 4 items of 4 documents
Fetuin-A serum levels are not correlated to kidney function in long-lived subjects
2012
Objectives: Serum Fetuin A has been identified as an inhibitor of ectopic calcification. It is reduced in subjects with chronic kidney disease (CKD) and it has been proposed as a potential link between CKD and the higher prevalence of arterial calcification observed in these patients. During ageing both the stiffening of arterial wall due to calcification and a decline in kidney function are frequent. The aim of the study is to investigate if Fetuin A serum levels are associated with ageing and with AHSG T256S polymorphism. Moreover, we aim at investigate whether serum Fetuin A is correlated to kidney function in this setting of senescence. Design and Methods: 256 health long-lived subjects…
Intravascular Lithotripsy for Treatment of Calcified Lesions During Carotid Artery Stenting
2020
Purpose: To report the use of intravascular lithotripsy (IVL) in the treatment of calcified carotid artery lesions. Materials and Methods: The records of 21 high-surgical-risk patients (mean age 75.1±8.1 years; 17 men) who were treated at 8 centers for carotid artery stenosis ≥70% were retrospectively reviewed. Twelve patients had a history of cerebrovascular disease. All patients had heavily calcified carotid artery lesions: 19 de novo and 2 in-stent restenoses (ISR). The mean baseline stenosis was 82.3%±9.7%. IVL was utilized at the discretion of the operator, followed by balloon angioplasty. Embolic protection devices were used in all cases. Results: In 19 patients, IVL was followed by s…
The Mode of Calcification in Atherosclerotic Lesions
1977
Calcific deposits in atherosclerotic plaques are usually considered to be an end stage of advanced atheroma formation. Postmortem studies of coronary arteries showed that pronounced atherosclerotic calcifications are strongly associated with stenosis of the involved segments and ischemic myocardial lesions (Eggen et al. 1965; McCarthy and Palmer 1974). A close correlation has also been found between calcific lesions detected by fluoroscopy or cinefluorography and clinical coronary artery disease (Oliver et al. 1964; Wartburton et al. 1968). Therefore, arterial calcification detected during life may be of important prognostic significance. Moreover, larger calcific plaques may influence the …
Bisphosphonates and atherosclerosis: why?
2005
The increasing knowledge on bone calcification processes has revealed some similarities with vascular tissue, where calcifications of arteries and cardiac valves contribute to several cardiovascular problems, such as heart failure, systolic hypertension, and myocardial and peripheral ischemic disease. Bisphosphonates have been used extensively for over two decades for the treatment of diseases associated with excessive bone resorption, i.e., osteoporosis, osteolytic bone metastasis, hypercalcemia and Paget’s disease, by blocking osteoclastic function. Etidronate, pamidronate and clodronate has been shown to inhibit the development of experimental atherosclerosis, and proposed mechanisms fo…